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For example, liraglutide, a GLP-1 receptor agonist, improved cognitive function in n = 19 patients with major depressive disorder (MDD) or bipolar disorder in a pilot randomised controlled trial (RCT) [16], whilst a systematic review and meta-analysis reported a pooled reduction in depressive symptoms with GLP-1 receptor agonists compared to other antidiabetic therapies [17]
Among the new findings presented were that a higher percentage of participants with pre-diabetes at baseline achieved normal blood glucose at week 64 in the semaglutide group versus placebo - 71.1% versus 33.3% - while those achieving 15% weight reductions or more, saw clinically meaningful benefits in CRP and triglycerides as well as reduced blood pressure
This shift not only more accurately captures the essence of the disease but also provides a clearer direction for its diagnosis and treatment [1]
