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Dermal fibroblast isolation All animals were anaesthetized with ketamine (75 mgkg 1 ) and xylazine (10 mgkg 1 ), and their dorsal hair was carefully removed

If you were experiencing symptoms like numbness or tingling in your hands and feet due to B12 deficiency, you may notice these symptoms gradually improve with continued treatment over several weeks

Under constant exposure, receptors are pulled off the cell surface and become less responsive over time (receptor desensitization). Higher doses maintain more signal against that fade

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Pharmacol Res

Its safety in humans is completely unknown