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In the last ten years, colistin has experienced a renewed clinical interest as a last resort for the treatment of multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus , vancomycin-resistant enterococci and some Gram-negative bacilli like Pseudomonas aeruginosa , Acinetobacter baumannii and Enterobacterales 1,2

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Table 1 provides a summary of skeletal phenotypes of the various igf-1 and igf-1r knockouts of relevance to bone

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