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mechanism unexplained Relative contributions of direct peptide effects versus downstream IGF-1 actions inadequately characterized Long-term receptor sensitivity and potential for desensitization inadequately studied Individual patient variability in response not well-characterized Potential for differential effects based on endogenous growth hormone status unclear Long-Term Safety Considerations Critical safety questions remain unanswered regarding chronic peptide administration: Cardiovascular safety concerns FDA warnings cite risks of increased heart rate, systemic vasodilation, flushing, and transient hypotension Immunogenicity risks FDA identifies both peptides as potentially immunogenic with risk of serious immune reactions including anaphylaxis Cancer risk theoretical concern that chronic growth hormone/IGF-1 elevation could promote cellular proliferation
Semaglutide is a peptide, and peptides are sensitive to temperature, light, and contamination
Phytomedicine 113 , 154539 (2023)
However, as with any medication, rare but serious risks (such as pancreatitis or gallbladder disease) can occur
Kiriakidis, S
Laboratory tests usually include urinalysis, blood test or urine culture
