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Chappell D, Jacob M, Hofmann-Kiefer K, Bruegger D, Rehm M, Conzen P, Welsch U, Becker BF

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Clearance of a drug is the factor that predicts the rate of elimination in relation to the drug concentration (C): Clearance, like volume of distribution, may be defined with respect to blood (CL b ), plasma (CL p ), or unbound in water (CL u ), depending on where and how the concentration is measured

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However, fat stores (i.e., epididymal white adipose tissue) were not significantly depleted in liver-specific Gclc KO mice