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Renal excretion of unchanged fentanyl is negligible, and active metabolites do not significantly affect clinical outcomes (71)

The SURPASS-2 trial, which directly compared tirzepatide 15mg to semaglutide 1mg, found tirzepatide produced greater reductions in LDL cholesterol (11.4% vs 7.9%) and triglycerides (23.5% vs 16.2%) at 40 weeks

It cites weight loss of 5 to 10% as enough to reduce lupus activity scores and improve response to disease-modifying medication

doi: 10.1371/journal.pone.0082346

Medical Uses and Benefits Semaglutide is primarily used to treat type 2 diabetes, a condition where the body does not use insulin properly

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