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She reviews the patients other medications and decides whether adding GLP-1s will do more harm than good

Avoid temptation increasing dose or frequency thinking "more is better." Stable effective protocol through completion then reassess need for continued treatment versus tapering

Impaired kidney function is also associated with increased IGFBP levels (e.g., IGFBP-1, -2, -3, -4, and -6) (75, 77) and IGFBP-3 protease activity, which subsequently increases low-molecular-weight IGFBP-3 fragments (78), most likely due to a compromised renal IGFBP-clearance ( Figure 4 )

Keidar A, Hershkop KJ, Marko L, Schweiger C, Hecht L, Bartov N, Kedar A, Weiss R

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

10.1006/bbrc.1998.9489 59 WeyerC.MaggsD