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Examines NNMT regulation in hepatic tissue and its relationship to fasting states and lipid metabolism, providing mechanistic context for NNMT inhibitor research

Choline and inositol play physiological roles in lipid transport, but administering supraphysiological doses via injection has not been proven superior to dietary intake or oral supplementation

Hoyer-KimuraCHayMKonhilasJPMorrisonHWMethajitMStromJet al

But the insights around GLP-1 receptors and the nodose ganglion may be one of the most intriguingand clinically actionablepieces of the puzzle so far

2005 Jun;185(3):401-13

An anti-nausea medication stops the urge to throw up