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Oral tirzepatide works by activating two hormone pathwaysGLP-1 and GIP receptorsthat regulate hunger and blood sugar, with clinical trials showing an average weight loss of 1522% over six months

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Elevated ROS levels increase vascular permeability and leakage of plasma components, contributing to the development of retinopathy [184]

However, in patients who develop chronic conditions, this oxidative fire is never successfully extinguished, leading to sustained collateral damage to the hosts own tissues

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