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The animals used in the study were consistently between four and six months of age, ensuring developmental consistency across experimental groups [1]

Among them, synovial macrophages (SMs) are known as the most prominent cells responsible for lesion formation and aggravation

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The flavonoid glycoside icariin has been shown to increase the expression of Nrf2, HO-1, and GPX4, in cisplatin-treated mouse ovarian tissues and KGN cells, which may contribute to reduced OS and ferroptosis (Li F

Catucci G, Querio G, Sadeghi SJ, et al