Continuous administration of a powerful growth factor can lead to receptor downregulation, diminishing its effects over time
This review ultimately incorporated 19 studies, comprising prospective observational studies, large-scale retrospective cohorts, active-comparator new-user cohort designs, and multiple randomized controlled trials (RCTs)
Hepatology 31 , 391398, doi: 10.1002/hep.510310219 (2000)
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