The FDA agreed in September 2025 to accept lean mass and fat mass as co-primary endpoints, which could set a regulatory precedent for the entire category
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Tirzepatide's starting price is also unchanged at $399 , but Willow no longer publicly lists the previous $499 price for 10 mg and 12.5 mg or $524 price for 15 mg
Additionally, GLP-1RAs or dual GIP/GLP-1 receptor agonists have been combined with other nutrient-based hormone (e.g., glucagon and amylin) receptor agonists (7782), a detailed discussion of which is beyond the scope of this review
This likely relates to the combined effects of both hormones on the digestive system
Conversely, GLP-1RAs may exert direct effects on the brain, depending on their ability to cross the bloodbrain barrier (BBB)