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Disruptions in detoxification and mitochondrial function may also interfere with melatonin production and restful sleep cycles

UV exposure on freshly treated skin is the leading driver of post-inflammatory hyperpigmentation across all skin types but the consequence is more visible and more durable in darker tones

However, another randomized, double-blind, placebo-controlled trial in 181 patients with diabetic neuropathy found that oral supplementation with either 600 mg/day, 1,200 mg/day, or 1,800 mg/day of lipoic acid for five weeks significantly improved neuropathic symptoms (77)

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Mean and standard error was calculated for all quantitative experiments

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