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Jiang Y, Berry DC, Jo A, Tang W, Arpke RW, Kyba M, et al

Although not head-to-head comparisons, these results show a progressive enhancement of efficacy across incretin-agonist generations, positioning retatrutide as a likely pharmacological evolution of tirzepatide

Pen-2 is essential for -secretase complex stability and trafficking but partially dispensable for endoproteolysis

This fermentation, though less extensive than with other fibre types, can produce short-chain fatty acids (SCFAs) such as butyrate, propionate, and acetate, which may stimulate L-cells in the colon to secrete GLP-1

pp 459465 Fritz IB