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Noneither CJC-1295 nor MK-677 suppresses endogenous GH production through negative feedback, so there is no recovery period required for the hypothalamic-pituitary axis to resume normal function

This enhancement is particularly relevant for conditions characterized by SOD dysfunction, where hydrogen water may both directly neutralize harmful radicals and boost the body's natural SOD productionoffering more comprehensive protection than either approach alone

That distinction is part of why it attracted research interest, and part of why the story is more complicated than vendor pages suggest

doi: 10.1053/jren.2003.50010

PMID 4528109

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