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M1-dominant macrophages overproduce TNF- and IL-6, directly blocking insulin receptor signalling in metabolically active tissues [4]

How Health Canada framed the decision Health Canada said in an April 28, 2026 announcement that it had authorized the first generic semaglutide injection, calling it the first such approval in the G7 [Source: canada.ca/en/health-canada/news/2026/04/canada-becomes-the-first-g7-country-to-approve-a-generic-version-of-semaglutide.html]

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Thus, the co-ordinated action of transcriptional co-activators and co-repressors tightly control the TH-mediated gene transcription in cells