metformin and glp 1 for weight loss in Maintenance: A Possible Opportunity Post-GLP-RA Discontinuation?- Dr. Ashok Kumar Das GLP-1 vs. Metformin… let's simplify

Lombard et al., 2001

The research literature differs in shape: AOD-9604 research base centers on the Metabolic Pharmaceuticals development program plus mechanism research on lipolytic activity Tesamorelin research base spans GHRH analog pharmacology plus the FDA-approved pharmaceutical clinical literature Application Comparison The mechanisms translate to different research applications: AOD-9604 research applications: Lipolytic mechanism research Fat metabolism studies Receptor-independent GH biology research Research on isolated lipolytic activity without IGF-1 effects Tesamorelin research applications: GHRH receptor pharmacology Pituitary GH axis research Multi-system effects of endogenous GH release (IGF-1 effects, downstream signaling) DPP-4-resistant peptide modification research These are different research applications with minimal overlap

Speciale A, et al

But most adults more than 60% say that Medicare policy should be changed to include coverage for these drugs when prescribed for weight loss

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2025 Mar;169(3):e70038