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Cardiovascular benefits The SELECT trial a landmark cardiovascular outcomes study involving over 17,000 participants showed that semaglutide reduced the risk of major cardiovascular events (heart attack, stroke, cardiovascular death) by 20% in people with obesity who did not have diabetes

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Practical Considerations Side Effects While highly effective, GLP-1 medications can cause gastrointestinal side effects such as nausea, constipation, or diarrhea

The most successful results are seen in patients who are fully committed to a comprehensive weight management program

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Clinical studies show maximal reduction in ALT levels (a marker of liver damage) was achieved approximately 28-30 weeks after starting treatment 20