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Patients with known gastrointestinal tract malabsorption may fail to absorb oral NAC appropriately, potentially resulting in reduced efficacy, and may be better served with parenteral administration [84]

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Vagus nerve stimulation can lead to gastrointestinal improvements (240), e.g., can increase gastric emptying through acting on the pyloric sphincter (241) and may be a treatment for gastroparesis (242)

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