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This finding supports that the above PRKAR1A mutation identified in tumor tissue is somatic in origin

Regarding treatment strategies, it is suggested that the marked decrease in GPx1 expression may be the major mechanism of tumor sensitization to anthracyclines [93] and that GPx1 can partially inhibit doxorubicin-induced cell death-related signaling in breast cancer by interfering with the activation of the sphingomyelin-ceramide pathway [85]

However, when the patent expires, other manufacturers can produce its generic version

P., and Graham, W

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