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Nonetheless, it should be stressed that for SARS-CoV-2 the importance of syncytia for either infection or pathogenicity remains to be proven, although our findings at least suggest a means by which this could be tested by examining the effect of making changes in the cytoplasmic tail that reduce the cell surface expression of S, and hence the rate of syncytia formation, without otherwise affecting viral replication

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Harling L, Rasoli S, Vecht JA, et al