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In the SURPASS 2 trial, Tirzepatide at all doses (5mg, 10mg and 15mg) was found to result in greater weight loss than semaglutide 1mg
Other common side effects reported in 5% or more of people in clinical trials include: Digestive system Indigestion (dyspepsia) Abdominal pain or upper abdominal pain Gastroenteritis (stomach bug) Increased lipase levels (a pancreatic enzyme, detected on blood tests) General Headache Fatigue (feeling tired) Dizziness Fever Other Injection site reactions such as redness, irritation, or bruising Low blood sugar (hypoglycemia), particularly if you also take insulin or a sulfonylurea Contact your doctor if any side effects are severe, persistent, or affecting your daily life