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What the Research Actually Shows A 2025 systematic review and meta-analysis of 16 randomized controlled trials found that black seed supplementation in adults with type 2 diabetes was associated with meaningful reductions in: Fasting blood glucose HbA1c Total cholesterol LDL (bad) cholesterol However, the same analysis found no significant improvement in post-meal glucose, fasting insulin, triglycerides, HDL cholesterol, body weight, or BMI

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