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Molecular medicine reports

This dual GIP/GLP-1 receptor agonist, approved by the FDA for type 2 diabetes and chronic weight management, may cause dizziness through several mechanisms including dehydration from gastrointestinal side effects, medication interactions affecting blood pressure, hypoglycemia when combined with insulin or sulfonylureas, and orthostatic hypotension related to weight loss

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CXXC5 tips this balance toward inhibition

Native human GLP-1 has a roughly two-minute half-life, so an exendin-4-based long-acting analog was the practical entry point for the drug class