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If the GLP-1/GIP/glucagon receptor class shows disease-modifying behaviour in OA rather than just mechanical pain relief from weight loss, it expands the scientific rationale for the compound and reinforces the argument that the triple-agonist mechanism is doing more than suppressing appetite

The UC Irvine IACUC is fully accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care International and adheres to the principles of the Guide for the Care and use of Laboratory Animals

doi: 10.1128/mSphere.00059-21 6 LuytCEHekimianGKoulentiDChastreJ

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These alterations are linked to the loss of vascular smooth muscle cell contractile ability, which is related to increased reactive oxygen species levels and decreased adenosine triphosphate generation [80]