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This process is particularly pronounced when glutathione (GSH) is depleted or glutathione peroxidase 4 (GPX4), a key enzyme that prevents lipid oxidation, is inhibited [39]

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The experimental approaches outlined in these application notes support several key research applications in cardiovascular drug discovery and nutraceutical development: Recent advances in in vitro atherosclerosis modeling , including sophisticated 3D systems, tissue-engineered blood vessels, and vessel-on-a-chip technologies, offer enhanced physiological context for future this compound research [1]

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