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Introduction# Retatrutide and survodutide represent two next-generation approaches to obesity and metabolic disease treatment that go beyond single-target GLP-1 receptor agonism

the P c ir value represents the predicted effective human jejunal permeability of the molecule (Table 10) the predicted P e n- value for dihexa (1.78) is intermediate between the predicted P e ff values for enalapril (1.25) and piroxicam (2.14), two orally bioavailable drugs, dihexa was also predicted to be 22.59 percent unbound to plasma proteins in circulation, thus making it available for distribution into the tissues

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10.2337/dc10-1710 70 GkeB.HershonK.KerrD.Calle PascualA.SchweizerA.FoleyJ.et al (2008)

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