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During the condensation of farnesylpyrophosphates to squalene, the enzyme farnesyl-diphosphate farnesyltransferase 1 (commonly called squalene synthase) utilizes a mole of NADPH during the reduction of a carbon-carbon double bond (-C=C-)

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As expected, the K8A mutation significantly reduced the enzymatic activity of OsDHAR (Fig

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L-Carnitine transports fatty acids into the mitochondria Ca-AKG supports the Krebs cycle (core energy metabolism) CoQ10 supports ATP production (usable energy) Vitamin B12 contributes to normal energy metabolism If one step slows down, the whole system becomes less efficient