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Given potential sex differences, we also conducted sex-specific analysis using individual data from the UK Biobank

This can make it difficult to move or perform daily tasks

Improves flexibility and joint mobility

Data generated from forced degradation studies informs: Selection of stability-indicating impurities Justification of impurity limits Identification of impurities requiring reference standards Long-term stability monitoring strategies This linkage ensures that impurity control remains proactive rather than reactive throughout the product lifecycle

For women, estrogen regulates the menstrual cycle and is imperative for reproduction

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