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This activation leads to the proliferation and migration of endothelial cells, as mediated by growth factors such as VEGF and Platelet-derived Growth Factor ( PDGF ), thus resulting in the formation of a complicated and disordered tumor vasculature

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Exposure to SGLT2 inhibitors from postnatal day 21 to 90, the period functionally coinciding with the late second and third trimesters of human pregnancy regarding kidney development, caused dilatation of the renal pelvis and tubules ( Table 2 )