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After the plasma membrane carrier-mediated GSH release from the cell, GSH becomes accessible to the active site of - glutamyl transpeptidase, which catalyzes the breakdown of the GSH - glutamyl bond forming two fractions: The -glutamyl fraction and the cysteinyl-glycine by transferring the -glutamyl fraction to an amino acid acceptor, forming -glutamyl-amino acid

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doi: 10.1016/j.brainres.2018.04.031 207 WilkinsonM

Cold sensitivity correlates with metabolic changes and active weight loss, but it is not a reliable indicator of treatment success

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