As with all GLP-1 receptor agonists and incretin-based therapies, the most commonly reported adverse effects in the Phase 2 trial were gastrointestinal in nature
Contraindications Do Not Use If You Have known hypersensitivity to NAD+ or any ingredient in the formulation Have active skin infection, open wounds, or severe skin conditions on the application area Warnings and Precautions Patch test first: Apply a small amount to an inconspicuous area and wait 24 hours before full-face application Avoid contact with eyes, mucous membranes, and broken skin Sun sensitivity: Use sunscreen during daytime use as retinoid-adjacent ingredients may increase photosensitivity Discontinue use and contact your provider if persistent irritation, burning, or rash occurs Common Side Effects Temporary redness or mild stinging on application Skin dryness or flaking Mild irritation, especially during first weeks of use Use in Pregnancy and Breastfeeding Safety during pregnancy and breastfeeding has not been established
The brand-name tirzepatide cost (Mounjaro and Zepbound) runs one thousand dollars to one thousand four hundred fifty dollars per month without insurance
Typical protocols range from 250-500 mcg daily, often split into twice-daily doses for optimal tissue levels
Acetyl-CoA is subsequently used for energy and ketone bodies production
Long-term avoidance without supplementation can lead to deficiency over time
