is tirzepatide a dual agonist GLP-1/GIP normalizes diabetic nephropathy via PI3K/AKT mediated suppression of oxidative stress Retatrutide vs Tirzepatide Compared |

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Baseline characteristics and treatment effects Baseline cohort characteristics were taken from the FLOW clinical trial for the full FLOW population, as well as for the two subgroups of patients receiving and not receiving SGLT-2 inhibitors at baseline (Supplementary Material, Table S1) [22,23,24]

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Administration and Storage Tirzepatide is given as a subcutaneous injection, meaning it goes into the fatty tissue just under the skin

Other commonly reported side effects include: Constipation , often manageable with fiber supplementation and hydration Diarrhea , particularly in the early weeks Bloating and gas Fatigue , especially during initial dose adjustment Injection site reactions including redness or itching Most of these side effects are mild to moderate and resolve within the first 2-4 weeks at any given dose