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Early analyses suggest that retatrutide produces a body composition shift comparable to tirzepatide, where approximately 25-35% of total weight loss comes from lean mass and 65-75% from fat mass

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FSP1 is a protein that inhibits ferroptosis, compensates for GPX4 deficiency, and exerts a protective effect on ferroptosis

Pharmacogenetic indicators, such as polymorphisms in DPYD, TYMS, GSTP1, and ABCC2, have been linked to toxicity in patients undergoing fluoropyrimidine and oxaliplatin-based treatments [269, 270]