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M1/M2 Macrophage Polarization in Human Obese Adipose Tissue

[DOI] [PubMed] [Google Scholar] Tornehave D

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Simultaneously, the proportion of pro-inflammatory species ( Ruminococcus gnavus , Fusobacterium nucleatum , Prevotella copri ) increases, enhancing pro-inflammatory cytokine secretion and reducing SCFA production along with tryptophan-derived immunomodulatory metabolites, thereby promoting insulin resistance (Huda et al., 2021)

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As fat tissue is lost quickly, the mechanical loading on your skeleton changes, and without adequate calcium, D3, and K2, bone mineral density can decline faster than it should