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Others may be dealing with insulin resistance, thyroid changes, menopause, PCOS, poor sleep, chronic stress, emotional eating, or medications that make weight easier to regain

Glutathione becomes oxidized, and so TTFD has can have a depleting effect on GSH and increase the requirement for recycling

doi: 10.1016/j.phrs.2023.106930

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Even modest weight loss of 5 to 10 percent can lead to meaningful improvements in blood sugar, blood pressure, metabolic liver disease, sleep apnea, joint pain, cardiovascular risk, and overall health

Exp Gerontol 175:112141 Alizaei Yousefabadi H, Niyazi A, Alaee S, Fathi M, Mohammad Rahimi GR (2021) Anti-inflammatory effects of exercise on metabolic syndrome patients: a systematic review and meta-analysis