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Systemic MOTS-c treatment prevents pancreatic -cell senescence and pancreatic insulitis in NOD mice While T1D is primarily recognized as a T cell-mediated disease, mounting evidence underscores the significance of non-cell-autonomous activities of senescent -cells in type 1 diabetes and suggests that the targeted elimination of SASP-producing senescent -cells can prevent autoimmune pancreatic insulitis 2

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