530 One of the major role-players in this are the small population of pluripotent cells residing within the tumor, known as cancer stem cells (CSCs)
coli variants with the Thr35 Asp and Thr35 Asp/Asn37 Ser/Arg57 His mutations in the active site were compact and have pronounced secondary structure, they did not possess rigid 3D structure and were 10 times more susceptible to limited trypsinolysis in comparison with the wild type protein, emphasizing low proteolytic stability of these intrinsically disordered molten globular mutants (Leontiev et al., 1993)
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One step towards resolution would be to combine the cerebrospinal fluid specimens for standardized targeted mass spectrometry analysis followed by multivariate analysis of age, gender, exercise status and levels of severity such as poor quality of life, pain, fatigue and interoceptive complaints