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Most patients experience mild, temporary gastrointestinal side effects including nausea, vomiting, constipation, or diarrhea during the first 2-4 weeks as the body adjusts to hormone activationthese typically resolve as tolerance builds

A 40-unit dose falls well within the tested therapeutic range and produced average weight loss of 20% or more in trial participants

doi: 10.1038/nature22350 20 PeyronCTigheDKvan den PolANde LeceaLHellerHCSutcliffeJGet al

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New England Journal of Medicine, March 2023 In this Perspective piece, researchers at Vanderbilt University create a series of estimates about how much Medicare may have to spend annually on weight-loss drugs if the program eventually covers these drugs