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Dysregulation of IGF-1/GLP-1 signaling in the progression of ALS: potential target activators and influences on neurological dysfunctions

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There are some non-M1 and non-M2 restorative type macrophages, which have both anti-inflammation and anti-fibrogenic features, highly express matrix metalloproteinase (MMP), and have a LY6C low , F4/80 + phenotype (Kazankov et al., 2019)

Out of 573 screened patients, more than half did not make it into the trial