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When adverse effects occurred, they were typically mild and transient, with the most common being mild to moderate headaches (similar frequency to placebo groups), minor injection site reactions (redness, slight swelling), and gastrointestinal effects at higher oral doses (nausea, diarrhea)

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Unlike sulfonylureas or insulin, GLP-1 receptor agonists carry a low intrinsic risk of hypoglycemia when used as monotherapy

Nature (this issue) Zhang, D

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For instance, clinical trials revealed that 1.6% of patients on semaglutide developed gallstones, compared to 0.7% of those on a placebo