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The downstream effects from this are not often considered when treating patients, yet the science is there

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Eur J Dermatol 2006

Whilst these medications do not selectively 'burn' belly fat through direct mechanisms, clinical evidence demonstrates they promote significant overall weight loss, including reductions in visceral adipose tissuethe metabolically harmful fat surrounding internal organs

During the ROS production in the polyol pathway, when aldose reductase reduces glucose to sorbitol, excess glucose enters the polyol pathway (Figure 1) (34)

When we eat or engage in addictive behaviours, the brains reward system releases feel-good chemicals like dopamine