GLP-1 could be rapidly degraded by dipeptidyl peptidase-4 (DPP-4) (185)
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Moreover, free radicals generate many changes in the membranes of nerve cells, such as those occurring due to lipid peroxidation (such as polyunsaturated fatty acidsmembrane phospholipids), modification of membrane enzyme activity, oxidation of membrane protein thiol groups, disturbance of membrane transport, change of the antigenic character of membranes and deregulation of membrane potential [111]
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