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Studies measuring copper levels in users of GHK-Cu products have not shown clinically significant increases in systemic copper, and there are no reports of copper toxicity from GHK-Cu cosmetic use

Jul 2002;23(4):447-51

Konczol et al 2016), resulting in only non-psychoactive peripheral sympathomimetic effects following ingestion

They cannot by themselves establish: A safe human amount A safe route of administration Long-term human safety Interaction risks Reproductive or developmental safety Clinical effectiveness Which individuals, if any, might be suitable for an authorised use The number of animal papers should not be presented as equivalent to a programme of large, well-controlled human clinical trials

It rebuilds beneath the surface, which is why almost every GHK Cu peptide before-and-after photo worth taking seriously was captured weeks or months apart

Pharmacol Rev 65:779808