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GLP-1 receptor agonists promote overall fat loss by: Suppressing appetite, leading to reduced caloric intake Slowing gastric emptying, helping patients feel fuller longer Enhancing insulin sensitivity, which helps regulate fat storage Thus, the result is widespread weight loss across the entire bodybut where the weight comes off is determined by genetics, not personal preference

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Patients with high-sensitivity GLP1R variants typically feel effects within 24-48 hours, while others may need 5-7 days, helping set accurate expectations