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Several studies have demonstrated inflammatory changes in the brain of depressed patients 52,53,54

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This extended action increases the risk of side effects seen with prolonged GH elevation: facial flushing, water retention, joint stiffness, and numbness or tingling in hands (carpal tunnel symptoms)

J Clin Oncol 31(20):2627 Kotil K, Kirali M, Eras M, Bilge T, Uzun H (2007) Neuroprotective effects of acetyl-L-carnithine in experimental chronic compression neuropathy