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Converging purinergic and immune signaling pathways drive IL-6 secretion by Fragile X cortical astrocytes via STAT3

We found similar results when comparing activity dynamics in response to a multistep protocol and a single longstep protocol (Appendix Fig S5)

As biofilms progress to irreversible attachment and microcolony formation, EPS reduces immune clearance efficiency

The synergy depends on phased timing

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