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The phase 2 trial enrolled 338 adults with obesity but without type 2 diabetes

These results show that GLP-1RA can induce phosphorylated AMPK expression (91), inhibit the expression and phosphorylation of the mTOR protein (92), promote the apoptosis of endometrial cancer cells, and thus play a potential anticancer role

Moreover, the analysis of lipid metabolism and inflammation regulators revealed higher gene expression of the fatty acid transporter cd36 , pparg , acc , hormone-sensitive lipase , tnfa and il6 in the peri-gonadal WAT of HFD-fed animals exposed to 3-BHA [210]