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Endocrine Reviews, 40 (1), 236267

The FDA-approved dosing schedule for Wegovy is: Week 1-4: 0.25 mg dose once weekly for the first 4 weeks (starting dose)/ Week 5-8: 0.5 mg dose once weekly Week 9-12: 1 mg once weekly, if needed Week 13-16: 1.7 mg once weekly, if needed Week 17 and beyond: 1.7 mg or 2.4 mg (maximum dose) The initial dose of Ozempic is 0.25 mg, which is injected once weekly for the first 4 weeks

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These drugs work by mimicking the action of endogenous GLP-1 but at supraphysiological doses, resulting in stronger and longer-lasting effects on appetite suppression

Pain reduction typically becomes clearly noticeable within 5 to 10 days

That investigation has now occurred (at least in preliminary form), and the human results are more reassuring than the animal data suggested