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Wang, F., Graham, W

Thermodynamic studies reveal that MT3 binds Cu + through enthalpy-driven processes and Zn + via entropy-driven mechanisms, forming Cu 4 thiolate clusters

In some embodiments, the otic formulation or composition comprises about 0.2% by weight of the povidone

HL: Writing original draft, Writing review & editing, Resources

One example is the use of self-assembling lysosomotropic nanoparticles formed from the combination of the potent autophagy inhibitor Lys-05 and the detergent MSDH, resulting in improved pharmacokinetics and superior antitumor efficacy in preclinical models

Lancet 397 , 22842303 (2021)